suppository technology.

Write out a prescription according to the order that regulates the rules for writing prescriptions. Describe the technology of suppositories by the rolling out method with full theoretical justification, taking into account the dosage of toxic and potent substances, as well as the rate of their one-time release, the physicochemical properties of the medicinal substances included in the prescription. Specify the criteria for assessing the quality of suppositories and the rules for issuing for release; give the corresponding calculations of the amount of medicinal substances and the base, write out the written control passport (back and front sides):

119. Take: Quinozola 0.03

Boric acid 0.1

Cocoa butter 1.5

Mix to make a ball

Give such doses in number 6

Designate. 1 ball per night.

120. Take: Ethacridine lactate

Novocaine 0.02 each

Enough cocoa butter Mix to make a candle

Give such doses in number 10

Designate. 1 candle 3 times a day.

121. Take: Demoiselle extract 0.015

novocaine

Streptocide 0.1 each

Solution of adrenaline hydrochloride 0.1% – 3 drops

Cocoa butter 3.0

Mix to make a candle

Give such doses in number 6

Designate. 1 suppository (for hemorrhoidal bleeding).

122. Take: Demoiselle extract 0.015

Novocaine 0.2

Adrenaline hydrochloride solution (1:1000) 3 drops

Enough cocoa butter

Mix to make a candle

Give such doses in number 10

Designate. 1 candle 2 times a day.

123. Take: Osarsola 0.1

Boric acid

Glucose 0.25 each

Cocoa butter 4.0

Mix to make a ball

Give such doses in number 10

Designate. 1 candle 2 times a week.

124. Take: Phenobarbital

papaverine hydrochloride

belladonna extract 0.015 each

Enough cocoa butter

Mix to make a candle

Give such doses in number 10

Designate. 1 candle per night.

125. Take: Anestezina

Novocaine 1.0

Dermatol 0.5

Enough basics

to make candles number 12

Give. Designate. 1 candle per day.

126. Take: Quinine hydrochloride 0.2

Boric acid 0.25

Cocoa butter 2.0

Mix to make a ball

Give such doses in number 12

Designate. 1 ball per night.

127. Take: Furacilina 0.02

Citric acid 0.05

Cocoa butter 2.0

Mix to make a ball

Give such doses in number 10

Designate. 1 ball per night.

128. Take: Demoiselle extract 0.015

Ichthyola

Xeroform 0.1

Cocoa butter 1.5

Mix to make a candle

Give such doses in number 12

Designate. 1 candle per night.

129. Take: Dikaina 0.01

belladonna extract 0.015

Xeroform 0.15

Novocaine 0.25

Cocoa butter 1.5

Mix to make a candle

Give such doses in number 10

Designate. 1 candle per night.

130. Take: Demoiselle extract 0.015

Analgin 0.5

Cocoa butter 1.5

Mix to make a candle

Give such doses in number 20

Designate. 1 candle 3 times a day.

131. Take: Platyphylline hydrotartrate 0.005

Papaverine hydrochloride 0.01

Dibazol 0.02

Anestezin 0.1

Enough cocoa butter

Mix to make a candle

Give such doses in number 20

Designate. 1 candle 3 times a day.

132. Take: Novocaine 0.25

Dimedrol 0.1

Adrenaline hydrochloride solution 0.1% 5 drops

Cocoa butter 3.0

Mix to make a candle

Give such doses in number 10

Designate. 1 candle 2 times a day.

133. Take: Papaverine hydrochloride 0.02

Caffeine – sodium benzoate 0.1 Cocoa butter 1.0

Mix to make a candle Give such doses as 6 Indicate. 1 candle per night.

134. Take: Norsulfazole 0.1

Streptocide 0.15

Enough cocoa butter

Mix to make a candle

Give such doses in number 10

Designate. 1 candle per night.

135. Take: Furazolidone 0.004

Cocoa butter 1.0

Mix to make a candle

Give such doses in number 15

Designate. 1 suppository 3 times a day rectally for 10-15 days.

136. Take: Demoiselle extract 0.015

Anestezin 0.25

Levomycetin 0.2

Novocaine 0.1

Enough cocoa butter

Mix to make a candle

Give such doses in number 10

Designate. 1 candle per night

137. Take: Chloral hydrate 0.5

Cocoa butter 2.0

Mix to make a candle

Give such doses in number 10

Designate. 1 suppository for epileptic seizures.

138. Take: Demoiselle extract 0.015

Novocaine 0.2

Xeroform 0.1

Cocoa butter 3.0

Mix to make a candle

Give such doses in number 6

Designate. 1 candle 2 times a day.

Write out a prescription according to the order that regulates the rules for writing prescriptions. Describe the technology of suppositories by pouring out on a fat basis (the form contains 3.0 fat base), taking into account the dosage of toxic and potent substances, the physicochemical properties of the medicinal substances included in the recipe; give the corresponding calculations of the amount of medicinal substances and bases; assessment of the quality of suppositories and the rules for registration for vacation, write out a written control passport (back and front sides):

139. Take: Streptocide 0.2

Boric acid 0.1

Glucose 0.3

enough butyrol

Mix to form a candle

Give such doses in number 6

Designate. 1 candle per night.

140. Take: Protorgola 0.05

Boric acid 0.1

Basics of polyethylene oxide sufficient quantity

Mix to form a ball

Give such doses in number 6

Designate. 1 ball 3 times a day.

141. Take: Osarsola 0.1

streptocide

Boric acid at 0.3 Butyrol is a sufficient amount

Mix to make a candle

Give such doses in number 12

Designate. 1 candle per night.

142. Take: Phenolic hydrophobic preparation of propolis 0.1 *

enough butyrol

Mix to make a candle

Give such doses by the number 20 Designate. 1 candle 3 times a day.

Phenolic hydrophobic preparation of propolis is a powder of light brown color, with a slight specific odor, hygroscopic, amorphous, soluble in water (obtained by extraction from propolis). Substance of the general list.

143. Take: Osarsola 0.1

Boric acid 0.15

Basics of gelatin-glycerin a sufficient amount

Give such doses in number 6

Designate. 1 candle per night.

144. Take: Protargol 0.1

Gelatin-glycerin base as needed

Mix to make a ball

Give such doses in number 12

Designate. 1 ball 3 times a day.

145. Take: Quinine hydrochloride 0.06

Tannin 0.015

A sufficient amount of gelatin-glycerin base

Mix to make a ball

Give such doses in number 6

Designate. 1 ball per night.

146. Take: Boric acid 0.1

Protargol 0.05

Gelatin-glycerin base as needed

Mix to make a ball

Give such doses in number 10

Designate. 1 ball vaginally 3 times a day.

147. Take: Etaminal – sodium 0.5

belladonna extract 0.015

A sufficient amount of gelatin-glycerin base

Mix to make a candle

Give such doses in number 5

Designate. 1 suppository for pain.

148. Take: Zinc oxide 0.25

Boric acid 0.1

A sufficient amount of gelatin-glycerin base

Mix to make a pessary

Give such doses in number 10

Designate. 1 pessary at night.

149. Take: Ichthyol 0.25

A sufficient amount of gelatin-glycerin base

Mix to form a pessary

Give such doses in number 10

Designate. 1 pessary 2 times a day.

150. Take: Diphenhydramine 0.1

Basics of polyethylene oxide sufficient quantity

Mix to make a candle

Give such doses in number 12

Designate. 1 candle in the morning and evening.

151. Take: Quinine hydrochloride

Boric acid 0.1 each

Basics of polyethylene oxide sufficient quantity

Mix to make a candle

Give such doses in number 10

Designate. 1 candle in the morning and evening.

152. Take: Streptocide 0.25

Basics of polyethylene oxide sufficient quantity

Mix to make a candle

Give such doses in number 20

Designate. 1 candle per night.

QUESTIONS FOR SELF-PREPARATION OF STUDENTS FOR THE COURSE EXAM AT THE 4th YEAR C/O IN DRUG TECHNOLOGY.

1. Drug technology as a scientific and academic discipline. Modern trends in the development of pharmaceutical technology. The role of domestic scientists, research institutions in the development of drug technology.

2. Biopharmacy. The concept of pharmaceutical factors and bioavailability of drugs.

3. Dosage forms. Classification of drugs by route of administration, state of aggregation. Rules for issuing medicines depending on the method of application. Order of the Ministry of Health of the USSR No. 583.

4.Dosing by volume. Measuring devices. Burette systems, their device, operating rules. Drop measurement.

5. Dosing by weight, classification of weights, metrological properties. Factors affecting the accuracy of weighing.

6. Poisonous, potent and narcotic drugs in the formulation of pharmacies: rules for prescribing, storing, dispensing, accounting. Orders No. 523 dated 07/03/68, No. 326 dated 11/10/97.

7. Powders as a dosage form, their classification. Basic operations in powder technology and their characteristics.

8. General rules for the preparation of complex powders and their theoretical justification.

9. Preparation of complex powders: with extracts, hard-to-grind substances, with liquids, with coloring and light-dusting substances. Examples.

10. Powders with poisonous, narcotic and potent substances. Triturations. Orders No. 523, 326. Examples of recipes.

11. Solvents used in drug technology, their characteristics. Obtaining purified water in pharmacy conditions, equipment. Orders: No. 309 of 10/21/97, No. 214 of 07/16/97.

12. True solutions, the theory of dissolution. Factors affecting the dissolution process. Straining and filtering solutions.

13. Special cases of dissolution. Preparation of solutions: iodine, potassium permanganate, silver nitrate, etc. Examples of recipes.

14. Rules for the preparation of liquid drugs by the mass-volume method. Order No. 308 dated 10/21/97. Recipe examples.

15. Preparation of concentrated solutions for burette installation and correction of their concentration.

16. Preparation of solutions from liquid preparations: Burov’s liquid, ammonia, acids, hydrogen peroxide, formalin, etc. Examples of recipes.

17. Non-aqueous solutions, preparation features, order No. 308 of 10/21/97. Examples.

18. IUD solutions: characteristics, preparation technology, examples of recipes.

19. Colloidal solutions: properties, stability factors, preparation. Recipe examples.

20. Suspensions as a dosage form. Stability factors, stabilization of suspensions.

21. Preparation of suspensions from hydrophilic and hydrophobic substances. Recipe examples.

22. Preparation of suspensions by the condensation method. Vacation decoration. Recipe examples.

23. Emulsions as dosage form and dispersion system. Definition, types of emulsions. Stability factors and stabilization of emulsions. Emulsifiers.

24. Oil emulsions: the rules of preparation, the introduction of medicinal substances. Storage and clearance for vacation.

25. Water extracts as a dosage form. Factors affecting the process and quality of extraction.

26. Preparation of aqueous extracts from raw materials containing essential oils, cardiac glycosides, alkaloids, tannins, mucus. Equipment.

27. Preparation of infusions and decoctions from standardized concentrate extracts. The introduction of medicinal substances into water extracts, registration for vacation. Recipe examples.

28. Ointments as a dosage form. Classification of ointments: according to the physical and chemical structure, purpose, consistency. Evaluation of the quality of ointments.

29. Classification of ointment bases. Characteristics of amphiphilic bases. Range.

30. Characteristics of hydrophilic ointment bases, assortment.

31. Characteristics of lipophilic ointment bases, assortment.

32. Preparation of ointments in a pharmacy: homogeneous ointments. Recipe examples.

33. Preparation of ointments such as suspensions, dermatological pastes. Registration of ointments for vacation. Recipe examples.

34. Preparation of emulsion and combined ointments. Recipe examples.

35. Liniments. Classification, preparation. Recipe examples.

36. Suppositories as a dosage form. Classification. requirements for them.

The introduction of medicinal substances into suppository bases. Evaluation of the quality of suppositories.

37. Suppository bases: classification, characteristics, requirements. Base assortment.

38. Preparation of suppositories by rolling and pressing. Applied equipment. Recipe examples.

39. Preparation of suppositories by pouring, equipment, calculations. Recipe examples.

EQUIPMENT LIST

1. Water distillers DE-4, DE-25, AEVS-4, 25, 60, AI-10.

2. Apparatus infunders AI-3, AI-3000.

3. A device for determining the time of complete deformation of suppositories.

4. Steam sterilizer.

LITERATURE

1. State Pharmacopoeia of the USSR.- Issue 2.- 11th edition, add.- M.: Medicine, 1989.-C19-24, 110-143.

2. State Pharmacopoeia of the USSR. 10th ed. – M.: Medicine, 1968.

3. Order of the Ministry of Health of the Russian Federation No. 309 dated 10/21/97 “On approval of the instructions for the sanitary regime”.

4. Order of the Ministry of Health of the Russian Federation No. 214 dated 16.07.97 “On quality control of medicines manufactured in pharmacies”.

5. Guidelines for the manufacture of sterile solutions in pharmacies / approved. MZ and MP 24.08.94/. -86 p.

6. Order of the Ministry of Health of the Russian Federation No. 305 dated 10/16/97 “Norms of deviations permissible in the manufacture of medicines and packaging of industrial products”.

7. Order of the Ministry of Health of the Russian Federation No. 308 dated 10/21/97 “On approval of instructions for the preparation of liquid dosage forms in pharmacies”.

8. Order of the Ministry of Health of the Russian Federation No. 326 dated 10.11.97 “On the rules for writing prescriptions for medicines and their dispensing”.

9. Order of the Ministry of Health of the Russian Federation No. 377 dated 11/13/96. “On approval of instructions for organizing storage in pharmacies of various groups of medicines and medical devices”.

10. Technology of dosage forms in 2 volumes. Textbook for high schools. T.1./ Ed. T.S. Kondratieva, – M .: Medicine, 1991, p. 496 .: ill., v. 2 / Ed. L.A. Ivanova – M.: Medicine, 1991, – 544 s: ill.

11.I.S. Azhgikhin, A.I. Tentsova. Dosage form and therapeutic efficacy of drugs. – M.: Medicine, 1976, – 336 p.

Each control work is carried out in a separate notebook, the front side of which is drawn up as follows:

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